What is the recommended height of the powder cake when filling capsules?

When filling capsules, the recommended height of the powder cake should be half the height of the capsule body. This guideline is important for several reasons. First, it allows for proper compression of the powder during the filling process. If the powder cake is too high, excessive powder can be introduced, leading to difficulties in capsule closure and possibly resulting in inconsistent dosages.

Maintaining the height at half the capsule body ensures that there is enough space within the capsule for movement and settling of the powder, allowing for uniformity when the capsule is closed and preventing spills. Moreover, this practice helps in achieving the correct amount of medication in each capsule, which is crucial for patient safety and effective treatment.

Moreover, filling capsules to the recommended height helps in providing a consistent dosage for the patient, minimizing variability, which is particularly important in pharmaceutical compounding.