What are the two neurotransmitters commonly associated with seizures?

The two neurotransmitters most commonly associated with seizures are glutamate and GABA. Glutamate is the primary excitatory neurotransmitter in the brain, and it plays a crucial role in synaptic transmission and neural excitability. When there is an excessive release of glutamate, it can lead to hyperexcitability of neurons, which is a significant factor in the development of seizures.

GABA, on the other hand, is the main inhibitory neurotransmitter in the central nervous system. It helps to counterbalance the excitatory effects of neurotransmitters like glutamate. A decrease in GABAergic inhibition or an imbalance between excitatory and inhibitory signals can also contribute to seizure activity. Thus, the interaction between glutamate and GABA is critical in maintaining the excitability of neuronal circuits and is central to the pathophysiology of seizures. This balance plays a significant role in the control of neuronal firing and seizure thresholds.