For what condition is promethazine primarily used and what is the maximum concentration allowed for IV use?

Promethazine is primarily used for the treatment of nausea and vomiting, particularly in situations such as motion sickness, postoperative nausea, and to alleviate nausea associated with certain medical conditions. It functions as an antihistamine and has antiemetic properties, making it effective for these purposes.

The maximum concentration allowed for intravenous (IV) use of promethazine is indeed 25mg/1ml. Administering promethazine at this concentration is important because higher concentrations can increase the risk of severe tissue damage, including necrosis, especially if the drug is extravasated. Thus, healthcare providers adhere to this concentration when preparing and administering promethazine IV to ensure patient safety while effectively managing nausea and vomiting.